姓名：王飞翼

职称职务：博士，教授，博士生导师，省级人才

E-mail：wangfyi@hubu.edu.cn

教育&工作背景

2016.07-至今： 湖北大学，教师

2019.01-2020.01： 美国Stanford University(斯坦福大学)，访问学者

2011.09-2016.06： 华东理工大学，精细合成化学与分子工程，博士

2006.09-2010.06： 湖北大学，化学工程与工艺，学士

科研简介

主要从事有机功能分子设计、合成及应用等方面的研究工作，包括荧光分子探针的构建、纳米荧光材料的制备、生物传感等。发展生物体内高时空分辨监测的分子影像技术，开发针对肿瘤等重大疾病的辅助诊疗新方法，为在生物医药、荧光传感材料、生态环境等交叉领域的创新应用提供科学依据和技术支撑。先后主持国家自然科学基金面上项目、青年基金项目、湖北省自然科学基金面上等项目10余项，以第一/通讯作者形式在Angew. Chem. Int. Ed., Chem. Sci.,Biomaterials,Chem. Eng. J.,Anal.Chem.,Chem. Eur. J.等高水平学术期刊上发表科研论文20余篇，授权中国发明专利6项。

主要科研项目

(1)国家自然科学基金面上项目，22178088，77.2万元，主持;

(2)国家自然科学基金青年项目，21702053，28.2万元，主持;

(3)湖北省自然科学基金面上项目，2020CFB601，主持;

(4)生物催化与酶工程国家重点实验室基金，SKLBEE2019017，主持;

(5)有机功能分子合成与应用教育部重点实验室基金，KLSAOFM1908，主持;

(6)湖北省科协“青年科技晨光计划”，2018年，主持;

(7)湖北省教育厅青年项目，2017年，主持

(8)THPO工艺优化项目，2019年，主持

(9)MB合成工艺技术开发项目，2022年，主持

(10)AT合成工艺技术开发项目，2022年，主持

(11)MB原料药有关物质研究开发，2023年，主持

代表性科研论文

(1)Zhengjun Wu, Dan Zhang, Hailong Ma, Erfei Wang*,Feiyi Wang*, Jun Ren*. Near-infrared colorimetric and ratiometric fluorescent probe for dual-channel imaging of mitochondria and cysteine in the oxidative stress model.Chem. Eng. J., 2023, 475, 146397.(IF: 15.1)

(2)Yajie Xu, Hailong Ma, Xianhong Su, Liangtao He, Erfei Wang*,Feiyi Wang*, Jun Ren*. A near-infrared self-assembled micellar nanoprobe for highly effective detection of cysteinein vitroandin vivo.Sens. Actuators B: Chem., 2023, 382, 133564.(IF: 8.4)

(3)Zhe Zhou, Xiaofeng Xia, Zheng Li, Tianshuo Zhou, Erfei Wang, Chao Ma*, Cuifen Lu, Junqi Nie, Guichun Yang, Juan Wang, Guorun Fan*, Jun Ren,Feiyi Wang*. An activatable near-infrared fluorescent probe for tracking nitroxylin vitroandin vivo.Dyes Pigments, 2023, 209, 110945.(IF: 4.5)

(4)Zheng Li, Xiaofeng Xia, Yu You, Cuifen Lu*, Guichun Yang, Chao Ma, Junqi Nie, Qi Sun*, Shuilin Wu, Jun Ren,Feiyi Wang*, Fast-response fluorescent probe with favorable water solubility for highly sensitive imaging of endogenous tyrosinase in living cells and zebrafish model.Chin. Chem. Lett., 2021, 32, 1785-1789.(IF: 9.1)

(5)Tianlin Wang, Qi Sun, Huiwen Xiong, Chao Ma, Cuifen Lu, Junqi Nie, Guichun Yang, Zuxing Chen, Yuexing Zhang*, Jun Ren,Feiyi Wang*, and Wei-Hong Zhu*. Rational Design of Fluorescent Probes: Improving Hydrophilicity, Ratiometric and NIR Trapping of Endogenous Leucine Aminopeptidase.Sens. Actuators B: Chem., 2020, 321, 128631.(IF: 8.4)

(6)Feiyi Wang*, Sisi Hu, Qi Sun, Qiang Fei, Chao Ma, Cuifen Lu, Junqi Nie, Zuxing Chen, Jun Ren, Guo-Rong Chen, Guichun Yang*, Xiao-Peng He*, and Tony D James*. A Leucine Aminopeptidase-Activated Theranostic Prodrug for Cancer Diagnosis and Chemotherapy.ACS Applied Bio Materials, 2019, 2, 4904-4910.(IF: 4.7)

(7)Sisi Hu, Tianlin Wang, Zhe Zhou, Cuifen Lu, Junqi Nie, Chao Ma, Guichun Yang*, Zuxing Chen, Yuexing Zhang, Qi Sun*, Qiang Fei, Jun Ren, andFeiyi Wang*.Highly chemoselective fluorescent probe for the detection of tyrosinase in living cells and zebrafish model.Sens. Actuators B: Chem., 2019, 283, 873-880.(IF: 8.4)

(8)Shaohua Yuan,Feiyi Wang*, Guichun Yang, Cuifen Lu, Junqi Nie, Zuxing Chen, Jun Ren, Yuan Qiu, Qi Sun*, Chunchang Zhao*, and Wei-Hong Zhu. Highly Sensitive Ratiometric Self-Assembled Micellar Nanoprobe for Nitroxyl and Its ApplicationIn Vivo.Anal. Chem., 2018, 90, 3914-3919. (Front Cover)(IF: 7.4)

(9)Feiyi Wang, Ge Xu, Xianfeng Gu, Zhijun Wang, Zhiqiang Wang, Ben Shi, Cuifen Lu, Xueqing Gong, Chunchang Zhao*. Realizing Highly Chemoselective Detection of H2SIn VitroandIn Vivowith Fluorescent Probes inside Core-Shell Silica Nanoparticles.Biomaterials, 2018, 159, 82-90.(IF: 14.0)

(10)Zhe Zhou,Feiyi Wang*, Guichun Yang, Cuifen Lu, Junqi Nie, Zuxing Chen, Jun Ren, Qi Sun*, Chunchang Zhao*, and Wei-Hong Zhu. A ratiometric fluorescent probe for monitoring Leucine aminopeptidase in living cells and zebrafish model.Anal. Chem., 2017, 89, 11576-11582.(IF: 7.4)

(11)Feiyi Wang, Ying Zhu, Li Zhou, Liang Pan, Zhifen Cui, Qiang Fei, Sihang Luo, Dun Pan, Qing Huang, Rui Wang, Chunchang Zhao*, He Tian, and Chunhai Fan*.Fluorescent In Situ Targeting Probes for Rapid Imaging of Ovarian-Cancer-Specificγ-Glutamyltranspeptidase.Angew. Chem. Int. Ed., 2015, 54, 7349-7353.(IF: 16.6)

(12)Feiyi Wang, Li Zhou, Chunchang Zhao*, Rui Wang, Qiang Fei, Sihang Luo, Zhiqian Guo, He Tian and Wei-Hong Zhu*. A Dual-Response BODIPY-BasedFluorescent Probe for the Discrimination of Glutathione from Cysteine and Homocysteine.Chem. Sci., 2015, 6, 2584-2589.(IF: 8.4)

(13)Feiyi Wang, Zhiqian Guo, Xia Li, Xiuai Li, and Chunchang Zhao*.Development of a Small Molecule Probe Capable of Discriminating Cysteine, Homocysteine, and Glutathione with Three Distinct Turn-On Fluorescent Outputs.Chem. Eur. J.,2014,20, 11471-11478.(IF: 4.3)

授权专利

(1)王飞翼,杨桂春,陈祖兴,卢翠芬,袁少华.一种比值式检测HNO的纳米荧光探针及其制备方法和应用,专利号：ZL 201810020079.2,授权公告号：CN 108342190 B。

(2)王飞翼,杨桂春,胡思思,陈祖兴,卢翠芬,聂俊琦,马超.一种检测酪氨酸酶的化合物及其制备方法和应用,专利号：ZL 201811523187.8,授权公告号：CN 109608474 B。

(3)王飞翼,杨桂春,柴云,陈祖兴,卢翠芬,聂俊琦,马超.一种检测HNO的化合物及其制备方法和应用,专利号：ZL201811537214.7,授权公告号：CN 109608495 B。

(4)王飞翼,陶林林,王天林,杨桂春,卢翠芬,马超,李峥,陈祖兴.一种二肽修饰的菁染料化合物及其制备方法和用途,专利号：ZL202010690292.1,授权公告号：CN 111909236 B。

(5)王飞翼;杨桂春;曾繁明;陈祖兴;马超;卢翠芬;聂俊琦;李峥。一种基于菁染料的化合物及其制备方法和用途。申请日：2020.05.05;授权日期：2023.03.24;专利号：ZL 202010369700.3; 授权公告号：CN 113603681 B。

(6)王飞翼，杨桂春，柴云，陈祖兴，卢翠芬，聂俊琦，马超。一种检测亮氨酸氨肽酶的化合物及其制备方法和应用，申请日：2018.09.17,授权日期：2022.05.10，专利号：ZL201811079565.8，授权公告号：CN 109438319 B。