• 姓       名:陈怀侠
  • 职       称:教授
  • 学       位:博士
  • 所在机构:湖北大学 化学化工学院
  • 出生年月: 1966年07月
  • 籍       贯:
  • E  - mail:hxch@hubu.edu.cn
  • 研究方向:现代分离技术;环境分析;食品分析;药物分析
个人简介 学术成果 发表论文

教育背景

1981-1988 武汉大学化学系分析化学专业学习,获理学学士和硕士学位

2002―2005武汉大学化学与分析科学学院分析化学专业获博士学位

学术兼职

教育部入库专家,中国化学学会会员。

教授课程

主讲“分析化学”及实验、“仪器分析”及实验和“现代分离技术”(本科生和研究生)等课程。

科研项目

主持国家自然科学基金、教育部重点基金项目、湖北省自然科学基金、湖北省教育厅重点基金项目和省科技厅科技攻关项目等20多项。

(1)国家自然科学基金“新型微污染物PPCPs及其代谢转化物分布调查和迁移转化规律研究”(20975030),主持人;

(2)国家自然科学基金重点项目“确有疗效复方中药痹祺胶囊的药代动力学研究”(30630075),主要成员;

(3)国家自然科学基金重点项目“新荧光探针标记磷酸化蛋白的毛细管电泳测定和细胞成像研究”(20575047),主要成员;

(4) 教育部科学技术研究重点项目“湖北地道药材黄连活性成分代谢及其与血浆蛋白结合研究”(208090),主持人;

(5) 湖北省自然科学基金“新型微污染物PPCPs及其代谢转化物分析研究”(2009CDB364),主持人;

(6) 湖北省科技厅科技攻关项目“莨菪烷类生物碱药代动力学药代产物研究”(2004AA301C106),主持人;

(7)湖北省教育厅重点项目“湖北省水环境中防晒剂污染分析及自然光降解研究”(D20120106),主持人;

(8) 省部共建教育部重点实验室项目“中药黄酮类化合物指纹图谱及含量测定研究”(2005-KL-009),主持人;

(9) 湖北省中药生物技术重点实验室开放基金“中药生物碱活性成分的代谢研究”(2005CTM001),主持人;

(10) 湖北大学人才专项基金“中药复方药物代谢研究”(ky2006004),主持人;

论文专著

发表科研论文100余篇,其中SCI收录78篇。

编写出版教材:

(1)《仪器分析实验》主编,科学出版社,2017年;

(2)《无机及分析化学》副主编,科学出版社,2009年;

(3)《无机及分析化学》主审,中国林业出版社,2012年。

代表性研究成果(30篇代表作):

(1) Jianli Zhu, Dongping Chen, Youhong Ai, Xueping Dang, Jianlin Huang, Huaixia Chen*. A dummy molecularly imprinted monolith for selective solid-phase microextraction of vanillin and methyl vanillin prior to their determination by HPLC. Microchim Acta 2017, 184(4):1161-1167.

(2) X Ma, F Feng, Y Yang, X Dang, J Huang, H Chen*. Magnetic Solid-Phase Extraction of N,N-Diethyl-m-Toluamide From Baby Toilet Water Prior to its HPLC-UV Detection. J Chromatogr Sci 2017, 55 (6): 662-668.

(3) Di Chen, Xiaoxuan Han, Qi Wang, Liujing Xie, Youhong Ai, Xueping Dang, Jianlin Huang, Huaixia Chen*. Magnetic molecular imprinted polymers for selective extraction and determination of naphthols. Microchim Acta 2017, 184: 3373-3379.

(4) Bin Sun, Chunpeng Wang, Qi Wang, Ling Chen, Xueping Dang, Jianlin Huang, Huaixia Chen*. Preparation of acryloyl β-cyclodextrin organic polymer monolithic column and its application in solid phase microextraction and HPLC analysis for carbofuran and carbaryl in rice. Food Anal Methods 2017, 10: 3847-3855.

(5) Yang Yang, Xiaowei Ma, Fan Feng, Xueping Dang, Jianlin Huang, Huaixia Chen*. Magnetic solid-phase extraction of triclosan using core-shell Fe3O4@MIL-100 magnetic nanoparticles, and its determination by HPLC with UV detection. Microchim Acta 2016, 183(8): 2467-2472.

(6) Bo Wu, Jinxia Li, Huaixia Chen*, Yong Ye. Fate of metronidazole under solar irradiation. Environ Eng Manag J 2016, 15(1): 1003-1008

(7) Xueping Dang, Chengguo Hu, Huaixia Chen, Jianlin Huang, Dongyun Zheng, Shengshui Hu. Photoelectrochemistry and sensor of NO based on a supramolecular system composed of polyhydroqinone and fullerene. Sensor Actuat B-Chem 2016, 228: 709-715.

(8) Ning Li, Quanfei Zhu, Yang Yang, Jianlin Huang, Xueping Dang, Huaixia Chen*. A novel dispersive solid-phase extraction method using metal-organic framework MIL-101 as the adsorbent for the analysis of benzophenones in toner. Talanta 2015, 132(15): 713–718.

(9) Xiaofang Liu, Shu Zhou, Quanfei Zhu, Yong Ye, Huaixia Chen*. Ultra preconcentration of polycyclic aromatic hydrocarbons in smoked bacon by a combination of SPE and DLLME. J Chromatogr Sci 2014, 52(8): 932-937.

(10) Quanfei Zhu, Chao Ma, Huaixia Chen*, Yaqi Wu, Jianlin Huang. A molecular imprint-coated stirrer bar for selective extraction of caffeine, theobromine and theophylline. Microchim. Acta 2014, 181(3-4): 303-311.

(11) Ting Yang, Chao Ma, Huaixia Chen*, Yajie Zhang, Xueping Dang, Jianlin Huang. A molecularly imprinted organic-inorganic hybrid monolithic column for selective extraction and high-performance liquid chromatography determination of isoprocarb residues in rice. J Sep Sci 2014, 37: 587–594.

(12) Xiaofang Liu, Quanfei Zhu, Huaixia Chen∗, Liuzi Zhou, Xueping Dang, Jianlin Huang. Preparation of 2,4-dichlorophenoxyacetic acid imprinted organic–inorganic hybrid monolithic column and application to selective solid-phase microextraction. J Chromatogr B 2014, (951-952): 32–37.

(13) Ting Zhang, Chao Ma, Mei Wu, Yong Ye, Huaixia Chen*, Jianlin Huang. Selective microextraction of carbaryl and naproxen using organic-inorganic monolithic columns containing a double molecular imprint. Microchim Acta 2013, 180: 695–702.

(14) Ting Zhang, Bo Wu, Na Sun, Yong Ye, Huaixia Chen*. Sorption and degradation of wastewater-associated pharmaceuticalsand personal care products in agricultural soils and sediment. Water Sci Technol 2013, 68 (5): 991-998.

(15) Xiaofang Liu, Na Sun, Quanfei Zhu, Mei Wu, Yong Ye, Huaixia Chen*. Preparation, characterization and application of organic-inorganic hybrid caffeine imprinted monolith. J Chromatogr A 2013, 1304: 10-17.

(16) Juan Li, Huaixia Chen*, Hui Chen and Yong Ye. Selective determination of trace thiamphenicol in milk and honey by molecularly imprinted polymer monolith microextraction and high-performance liquid chromatography. J Sep Sci 2012, 35 (1): 137–144.

(17) Shu Zhou, Huaixia Chen*, Bo Wu, Chao Ma, Yong Ye. Sensitive determination of carbamates in fruit and vegetables by a combination of solid-phase extraction and dispersive liquid-liquid microextraction prior to HPLC. Microchim Acta 2012, 176: 419–427.

(18) Shu Zhou, Bo Wu, Chao Ma, Yong Ye. Huaixia Chen*. Solid-phase extraction followed by dispersive liquid-liquid microextraction for the sensitive determination of carbamates in environmental water by high-performance liquid chromatography. J Liq Chromatogr R T 2012, 35: 1-13.

(19) Bo Wu, Ting Zhang, Jinxia Li, Yong Ye. Huaixia Chen*. The photodegradation of metronidazole in the presence of coexisting pharmaceuticals. Water Sci Technol 2012, 735-740.

(20) Na Sun, Shengli Wu, Huaixia Chen*, Daijun Zheng, Junwen Xu, Yong Ye. Determination of sulfamethoxazole in milk using molecularly imprinted polymer monolith microextraction coupled to HPLC. Microchim Acta 2012, 179: 33-40.

(21) Chao Ma, Hui Chen, Na Sun, Yong Ye, Huaixia Chen*. Preparation of Molecularly Imprinted Polymer Monolith with an Analogue of Thiamphenicol and Application to Selective Solid-Phase Microextraction. Food Anal Methods 2012, 5: 1267–1275.

(22) Jinfang Zhou, Chao Ma, Shu Zhou, Peili Ma, Fangrong Chen, Yue Qi, Huaixia Chen*. Preparation, evaluation and application of molecularly imprinted solid-phase microextraction monolith for selective extraction of pirimicarb in tomato and pear. J Chromatogr A 2010, 1217: 7478-7483.

(23) Huaixia Chen*, Jianlin Huang, Juan Li. Characterization of metabolites of worenine in rat biological samples using liquid chromatography–tandem mass spectrometry. J Pharm Biomed Anal 2010, 51: 236-243.

(24) Huaixia Chen*, Hui Chen, Lei Liao, Jun Ying, and Jianlin Huang. Determination of thiamphenicol in honey by dispersive liquid-liquid microextractionwith high-performance liquid chromatography. J Chromatogr Sci 2010, 48: 450-455.

(25) Huaixia Chen*, Hui Chen, Jun Ying, Jianlin Huang, Lei Liao. Dispersive liquid-liquid microextraction followed by high-performance liquid chromatography as an efficient and sensitive technique for simultaneous determination of chloramphenicol and thiamphenicol in honey. Anal Chim Acta 2009, 632:80-85.

(26) Huaixia Chen*, Yong Chen, Peng Du, Fengmei Han. Structural elucidation of in vivo and in vitro metabolites of anisodine by liquid chromatography-tandem mass spectrometry. J Pharm Biomed Anal 2007, 44: 773-778.

(27) B.Y. Ge, H.X. Chen, F.M. Han, Y. Chen. Identification of Amygdalin and its major metabolites in Rat Urine by LC-MS/MS. J Chromatogr B 2007, 857:281-286.

(28) Mingming Zhu, Fengmei Han, Huaixia Chen, Zhihong Peng, Yong Chen. Identification of palmatine and its metabolites in rat urine by liquid chromatography-tandem mass spectrometry. Rapid Commun Mass Spectrum 2007, 21(13):2019-2022. 引用8次(2013.4.7)

(29) Zhihong Peng, Wei Song, Fengmei Han, Huaixia Chen, Mingming Zhu, Yong Chen. Chromatographic tandam mass spectrometric setection of papaverine and its major metabolites in rat urine. Int J Mass Spectrom 2007,266: 114-121.

(30) Huaixia Chen, Yong Chen, Hong Wang, Peng Du, Fengmei Han, Huashan Zhang*. Analysis of scopolamine and its eighteen metabolites in rat urine by Liquid chromatography-tandem mass spectrometry. Talanta 2005, 67/5:984-991.

奖励/荣誉

中共湖北省委“优秀党务工作者”;

湖北省教学成果一等奖(排名第四);

湖北大学教学成果一等奖(排名第六);

湖北大学优秀党员;

湖北大学教学名师;

湖北大学2009年度和2001年度本科教学质量优秀奖;

湖北大学优秀教师;

湖北大学工会优秀女会员;

学校优秀教案三等奖。