编辑推荐: 该研究成果于2023年6月20日以“Versatile Biocatalytic C(sp3)–H Oxyfunctionalization for Site-selective and Stereodivergent Synthesis of α- and β- Hydroxy Acids”为题在线发表于Angewandt...
阅读全文从生化方法筛选得到的抑制剂是否在细胞内作用相同的靶标? 这是目前被制药界广泛争论的一个话题。为了得到答案,他们利用化学蛋白组学结合磷酸化蛋白组学对 SAA的活性作用机理进行了系统研究。首先 合成了炔基化 SAA...
阅读全文在钯催化剂前体和混合配体(双膦配体 dppf和双氮配体dmbpy)的作用下,各类取代的芳基酯基重氮、多氟芳烃和烯丙基底物可发生高效的三组份反应,从而快速构建一系列包含芳基和多氟芳基的 高度官能团化的全碳季碳中心 ...
阅读全文Credit: Redox Biology (2023). DOI: 10.1016/j.redox.2023.102736 Some cells in the human body can generate hypochlorite—the same chemical used to kill bacteria and viruses in household bleach. When h...
阅读全文Visible-light-driven photocatalytic hydrogen evolution reaction (HER) over a semiconductor provides an effective avenue to produce renewable clean energy and alleviate energy and environmental crises....
阅读全文Adam Hollerbach with a SLIM device created at Pacific Northwest National Laboratory. Credit: Andrea Starr | Pacific Northwest National Laboratory The universe is awash in billions of possible chemical...
阅读全文June 27, 2023 Editors' notes This article has been reviewed according to Science X's editorial process and policies. Editors have highlighted the following attributes while ensuring the content's cred...
阅读全文Depiction of the seeded supramolecular polymerization protocol (a) and the associated time-dependent changes (b). Supramolecular polymers obtained by open-ended and closed-ended seeds (c and d, respec...
阅读全文More than 20 enzymes are involved in the production of the 21R-citrinadin A molecule. Credit: Gustavo Raskosky/Rice University Many of the drugs we use to treat cancer and infectious disease are—or d...
阅读全文The biperiodic chemical trend and enhanced oxygen reduction reaction activity of Ln-MoS2. Credit: NIMTE A research group led by Prof. Wang Liping at the Ningbo Institute of Materials Technology and En...
阅读全文Credit: Physical Review Letters (2023). DOI: 10.1103/PhysRevLett.130.266301 Two new innovative methods describe how to measure the electrical resistivity of liquid iron—such as that found in planetar...
阅读全文Unroasted cacao beans, as shown here, feature unique fruity flavors that can be lost when they're processed at high temperature. Credit: Marlon Ac-Pangan "Natural" foods are trendy, and proponents cla...
阅读全文Credit: Environmental Science & Technology (2023). DOI: 10.1021/acs.est.3c01407 RNA, an essential biomolecule for life, has been used in environmental applications including monitoring microbial commu...
阅读全文Unusual phenanthrene-fused porphyrins were successfully synthesized via thermal conversion of precursor porphyrin, followed by intramolecular Scholl reaction. Credit: Ehime University Prof. Okujima, i...
阅读全文2023年5月30日,北京大学化学与分子工程学院、合成与功能生物分子中心、北大-清华生命科学联合中心、IDG/麦戈文脑科学研究所邹鹏课题组在《ACS Biochemistry》发表题为“Enzyme-Mediated Proximity Labeling Identif...
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